Research Scientist – Protein Chemistry

at AdvanBio (View all jobs)

Irvine, CA


AdvanBio has an immediate open position for the Research Scientist, Chemistry & Reagents.

We are looking for an experienced Scientist to develop reagents and assays to enable new on-chip capabilities for biological workflows, and transfer technology from R&D to manufacturing.  

Primary Responsibilities

  • Deliver new reagents, and assays to enable biological workflows on various platforms.
  • Drive R&D efforts to deliver reagents to enable new assays and protein characterization capabilities (western blot, IEF, SDS PAGE, SPR)
  • Examples of reagents include surface chemistry reagents, critical raw materials, and functionalized microparticles. Master in protein (HRP, AP, Acridinium, Biotin) and microparticle conjugation.
  • Lead Research Associates in the characterization and testing of new reagents. Design appropriate functional tests on various platforms to validate reagent and assay performance.
  • Work with internal teams to perform workflow testing on new reagents once lead candidates have been selected. Modify R&D directions and activities based on the data.
  • Oversee the technology transfer of new reagents from R&D to Manufacturing. This includes relevant documentation and appropriate quality control (QC) procedures. Support the scale-up of reagent manufacturing.
  • Collaborate with suppliers to synthesize custom reagents and characterize reagents using appropriate analytical techniques, as needed.
  • Work with other groups within the company to advance progress on development programs.
  • Act as a mentor to team members. Provide constructive coaching and timely performance feedback. Conduct formal reviews with team members.
  • Model technical problem-solving leadership to resolve issues that arise in R&D and be responsible for completing projects on time.
  • Collaborate with team members to design thorough, hypothesis-driven experiments to solve problems. Conduct careful, rigorous science. Make data-driven decisions and adjust technical directions as needed.
  • Present project updates and new R&D findings to executive management and relevant stakeholders.

Desired Skills and Experience

  • Ph.D.  in Chemical Engineering, Chemistry, Bioengineering, or a related discipline. An excellent academic record is a strong plus.
  • At least 3 years of industry experience.
  • Experience developing IVD and life science reagents.
  • Proficient in protein (HRP, AP, acridinium, biotin) and microparticle conjugation
  • Reagent development experience. Bio-conjugation experience – particularly involving the chemical modification and purification of proteins, peptides, and nucleic acids.
  • Prior experience with the synthesis and purification of protein-fluorophore conjugates.
  • Surface and interfacial chemistry expertise – especially with chemical modification and characterization of inorganic and polymeric surfaces.
  • Proficiency in analytical techniques used to purify and characterize both macromolecules and small molecules, such as chromatography (IEX, SEC, and affinity), fluorescence, and protein characterization techniques
  • Fundamental understanding of physical, chemical, and biological phenomena which govern biological assays. Experience with immunoassay assays is a plus.
  • Rigorous scientist with a record of developing robust, transferrable processes. Data-driven, proficient with the design of experiments (DOE), and statistical analysis.
  • Ability to thrive in a dynamic company with demanding schedules and deliverables.
  • Outstanding collaborative, interpersonal, verbal, and written communication skills to clearly articulate ideas, problems, and solutions within a highly interdisciplinary environment.


We offer a comprehensive benefits package including paid holidays and vacation, affordable medical, dental, life insurance, and retirement plans. You will be eligible for benefits on your first day of employment.

We are an Equal Opportunity Employer (U.S.). You will receive consideration for employment without regard to race, color, religion, national origin, age, citizenship, gender, marital status, pregnancy, sexual orientation, gender identity and expression, disability, or veteran status.

For interested applicants, please email your resume to [email protected].